"We are truly saddened by the passing of our client and friend, Chuck Blazer," his lawyers said in a statement.
"His misconduct, for which he accepted full responsibility, should not obscure Chuck's positive impact on international soccer."
The official served on Fifa's executive committee from 1997-2013, during which time he pocketed millions to fund a globe-trotting VIP lifestyle.
A 2013 report by Concacaf's integrity committee said he had received more than $20.6m (£16m) in commissions, fees and rental payments from the organisation between 1996 and 2011.
His personal excesses included two apartments in New York's Trump Tower, one of which was exclusively for his cats.
Analysis: A complex legacy
By Richard Conway, BBC Sports News correspondent
Chuck Blazer leaves behind a complex legacy to football.
He helped develop the game in the US and then across his confederation.
But he also personally enriched himself and was emblematic of the greed and corruption that festered within world football for many years.
However, it was his evidence that was instrumental in the arrest and prosecution of scores of Fifa and marketing executives, a process that became publicly known with dramatic dawn raids in Zurich in 2015 and is still continuing.